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Discover the PI3K Akt pathway and its crucial role in cell growth and survival. Click here to learn more & gain insights into this important signaling cascade
Information about the shelf life of our products can be found at the following link: Product Shelf-Life
Explore the NFkB pathway and its impact on inflammation and immune responses. Click here to learn more about this signaling pathway.
Western Blotting troubleshooting guide for easy to solve high and low background issues.
Learn about BCR signaling and how it can lead to changes in cell metabolism, gene expression, and cytoskeletal organization. Click here.
Ensure equal sample loading with loading control antibodies from CST.
β-Actin can be cleaved by caspase-3 between Asp244 and Gly245, which will result in a 32kDa fragment and a 15kDa fragment. Due to the location of its antigen, our β-Actin Antibody #4967 will detect both full-length β-Actin as well as the 32kDa fragment, also known as fractin.
The TGF-β Antibody #3711 detects recombinant TGF-β1, TGF-β2, and TGF-β3. The antibody also detects endogenous levels of the TGF-β1 precursor proteins. The different sizes we have listed represent the precursor TGF-β protein (45kDa), the mature dimer form (25kDa) and the monomer (12kDa).We do not usually detect the mature TGF-β at 25 kDa because mature TGF-β is composed of two polypeptides that are disulfide-linked. Therefore under reducing conditions, these polypeptides are separated and observed as a single band at 12 kDa. However, we have shown that the TGF-β Antibody #3711 can detect the mature form of TGF-β by using recombinant protein.TGF-β is rapidly exported from the cell and therefore may be difficult to detect in tissue or cell lysates. In human platelet samples, we observe two strong bands, with the larger band likely being the precursor (uncleaved) form at 45kDa and the smaller being the monomer at 12kDa.
We use the Octet® RED96.
Expert-reviewed interactive dopamine signaling pathway providing a current overview of Dopamine in Parkinson's Disease. Learn more here.
Highly specific and sensitive rabbit mAbs against B7 family targets, B7-H3 & B7-H4, are proven to outperform existing clones by WB.
An antibody shouldn’t be one of the variables in your experiment. Find out why customers rank CST highest for antibody specificity and sensitivity.
Oct 2007, CST announced the availability of PhosphoScan® profiling technology and PhosphoSite® knowledge base to academic researchers.
Designing or troubleshooting flow cytometry experiments to analyze intracellular signaling? Here’s what you need to know.
Cell Signaling Technology (CST) Drives Sustainability in the Life Sciences Through My Green Lab Sponsorship
CST is proud to partner with global green chemistry nonprofit Beyond Benign to support the creation of green chemistry teaching resources for STEM education.
A scientific resource for the 14-3-3 protein domain containing information on structure, function, and binding to phospho-serine and phospho-threonine motifs.
Cell Signaling Technology (CST) Enters Agreement with Roche for CDx Development
U.S. Patent No. 6,441,140, directed to the production of a novel class of motif-specific, context-independent antibodies, highly useful for the identification of subclasses of protein kinase substrates.