Cat. # | Size | Qty. | Price |
---|---|---|---|
33738T | 1 Kit (9 x 20 microliters) |
|
Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
---|---|---|---|---|---|
Complexin-1 (D5Q5H) Rabbit mAb 17700 | 20 µl |
|
H M R | 14 | Rabbit IgG |
Complexin-1/2 (D8A6E) Rabbit mAb 28070 | 20 µl |
|
H M R | 14-16 | Rabbit IgG |
Munc18-1 (D4O6V) Rabbit mAb 13414 | 20 µl |
|
H M R | 70 | Rabbit IgG |
SNAP25 (D7B4) Rabbit mAb 5308 | 20 µl |
|
H M R | 25 | Rabbit IgG |
Synaptophysin (D8F6H) XP® Rabbit mAb 36406 | 20 µl |
|
H M R | 38 | Rabbit IgG |
Synaptotagmin-1 (D33B7) Rabbit mAb 14558 | 20 µl |
|
H M R | 60 | Rabbit IgG |
Synapsin-1 (D12G5) XP® Rabbit mAb 5297 | 20 µl |
|
H M R | 77 | Rabbit IgG |
Syntaxin 1A (D4E2W) Rabbit mAb 18572 | 20 µl |
|
H M R | 33 | Rabbit IgG |
VAMP2 (D6O1A) Rabbit mAb 13508 | 20 µl |
|
H M R | 13 | Rabbit |
Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Goat |
Product Information
Complexin-1 (D5Q5H) Rabbit mAb is produced by immunizing recombinant protein specific to human complexin-1 protein. Complexin-1/2 (D8A6E) Rabbit mAb is produced by immunizing rabbits with a synthetic peptide corresponding to residues surrounding Pro125 of human complexin-2 protein. VAMP2 (D6O1A) Rabbit mAb is produced by immunizing recombinant protein specific to the amino terminus of human VAMP2 protein. All other monoclonal antibodies are produced by immunizing rabbits with synthetic peptides corresponding to Asp110 of human SNAP25, Val237 of human syntaxin 1A, Gly299 of human synaptophysin, Arg400 of human synaptotagmin-1, Gln483 of human synapsin-1, and Tyr157 of human Munc18-1.
The synapse is the unit of information transfer in the brain between neurons (1). Synaptic transfer is initiated by action potential-initiated synaptic vesicles fusion at the presynaptic terminal to release neurotransmitters. The basic molecular machinery that drives all membrane fusion events in all cells include N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that form a trans-ternary complex between to-be-fused membranes. The zippering up of SNARE proteins provides the energy required for membrane fusion. At the synapse, the SNARE proteins include 25 kDa synaptosome-associated protein (SNAP25), syntaxin 1A (STX1A), and vesicle-associated membrane protein 2 (VAMP2, also called synaptobrevin). Neurotransmitter release, however, is a highly regulated process that occurs in response to action potential-initiated Ca2+-influx. Regulation of synaptic vesicle fusion is mediated by SNARE-binding proteins like complexin and the Ca2+-associated vesicle protein, synaptotagmin-1, that cooperatively function to initiate Ca2+-induced synaptic vesicle fusion. The synaptic vesicle cycle represents a cycle of events that prime the synaptic vesicle before fusion and retrieve fused membrane after full fusion. Synaptic vesicle-associated proteins like synaptophysin and synapsin-1, as well as target membrane proteins like Munc18-1, play a complex role in priming synaptic vesicles to be fusion competent.
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