Name: Extracellular Matrix Dynamics Antibody Sampler Kit
Brand: Cell Signaling Technology
Availability: InStock

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Extracellular Matrix Dynamics Antibody Sampler Kit: Image 1 — Western blot analysis of extracts from various cell lines using CYR61 (D4H5D) XP^® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). As expected, MCF7 cells are negative for CYR61 expression.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 2 — Western blot analysis of extracts from Hs 578T and AN3-CA cells using Periostin (E5F2S) Rabbit mAb (upper) or GAPDH (D16H11) XP^® Rabbit mAb #5174 (lower). Negative expression of periostin protein in AN3-CA cells is consistent with the predicted expression pattern.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 3 — Immunoprecipitation of periostin protein from Hs 578T cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP^® Isotype Control #3900, and lane 3 is Periostin (E5F2S) Rabbit mAb. Western blot analysis was performed using Periostin (E5F2S) Rabbit mAb. Anti-rabbit IgG, HRP-linked Antibody #7074 was used as the secondary antibody.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 4 — Western blot analysis of extracts from various cell lines using Periostin (E5F2S)Rabbit mAb (upper) or GAPDH (D16H11) XP^® Rabbit mAb #5174 (lower). Negative expression of periostin protein in SW620 cells is consistent with the predicted expression pattern.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 5 — Immunohistochemical analysis of paraffin-embedded human prostate adenocarcinoma using Periostin (E5F2S) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 6 — Western blot analysis of extracts from various cell lines using Fibronectin/FN1 (E5H6X) Rabbit mAb (upper) and β-Actin (D6A8)Rabbit mAb #8457 (lower). The absence of Fibronectin/FN1 expression in PANC-1 cell extracts is consistent with molecular and proteomic expression profiling data, confirming specificity of the antibody.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 7 — Western blot analysis of extracts from RH-30 and IGROV-1 cells using Tenascin C (E5J3B) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). The differential in Tenascin C expression between RH-30 and IGROV-1 cells is consistent with their reported molecular expression profiles (CCLE, portals.broadinstitute.org), confirming specificity of the antibody for Tenascin C.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 8 — Western blot analysis of extracts from various cell lines using Thrombospondin-1 (D7E5F) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 9 — Western blot analysis of extracts from various cell lines using COL4A1 Antibody (upper) and β-Actin (D6A8)Rabbit mAb #8457 (lower). The absence of COL4A1 expression in HCT 116 cell extracts is consistent with molecular and proteomic expression profiling data, confirming specificity of the antibody.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 10 — Western blot analysis of extracts from RD and ACHN cells using COL3A1 (E8D7R) XP^® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). Differential expression of COL3A1 in RD and ACHN cell lines is consistent with molecular and proteomic expression profiling data, confirming specificity of the antibody for COL3A1.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 11 — Immunohistochemical analysis of paraffin-embedded human prostate adenocarcinoma using COL3A1 (E8D7R) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 12 — After the primary antibody is bound to the target protein, a complex with HRP-linked secondary antibody is formed. The LumiGLO^® is added and emits light during enzyme catalyzed decomposition.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 13 — Western blot analysis of extracts from various cell lines using COL1A1 (E8F4L) XP^® Rabbit mAb (upper) and GAPDH (D16H11) XP^® Rabbit mAb #5174 (lower).

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 14 — Western blot analysis of culture medium, from SPARC-secreting PYS-2 cells, using SPARC (D10F10) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 15 — Confocal immunofluorescent analysis of Saos-2 cells, untreated (left) or treated with Brefeldin A #9972 (10 μg/ml, overnight; center), and untreated MCF7 cells (right), using CYR61 (D4H5D) XP^® Rabbit mAb (green). Actin filaments were labeled with DyLight^™ 554 Phalloidin #13054 (red). Blue pseudocolor = DRAQ5^® #4804 (fluorescent DNA dye).

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 16 — Immunohistochemical analysis of paraffin-embedded human esophageal adenocarcinoma using Periostin (E5F2S) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 17 — Immunoprecipitation of Fibronectin/FN1 protein from Hep G2 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP^® Isotype Control #3900, and lane 3 is Fibronectin/FN1 (E5H6X) Rabbit mAb. Western blot analysis was performed using Fibronectin/FN1 (E5H6X) Rabbit mAb. Anti-rabbit IgG, HRP-linked Antibody #7074 was used as a secondary antibody.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 18 — Immunoprecipitation of Tenascin C protein from U-87 MG cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP^® Isotype Control #3900, and lane 3 is Tenascin C (E5J3B) Rabbit mAb. Western blot analysis was performed using Tenascin C (E5J3B) Rabbit mAb. Mouse Anti-rabbit IgG (Conformation Specific) (L27A9) mAb (HRP Conjugate) #5127 was used as the secondary antibody.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 19 — Immunoprecipitation of thrombospondin-1 protein from ACHN cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP^® Isotype Control #3900, and lane 3 is Thrombospondin-1 (D7E5F) Rabbit mAb. Western blot analysis was performed using Thrombospondin-1 (D7E5F) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 20 — Immunohistochemical analysis of paraffin-embedded human gastrointestinal stromal tumor using COL3A1 (E8D7R) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 21 — Immunohistochemical analysis of paraffin-embedded human endometrioid adenocarcinoma using COL1A1 (E8F4L) XP^® Rabbit mAb performed on the Leica^® BOND^™ Rx.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 22 — Immunohistochemical analysis of paraffin-embedded human colon carcinoma using SPARC (D10F10) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 23 — Flow cytometric analysis of 293T cells (blue) and PANC-1 cells (green) using CYR61 (D4H5D) XP^® Rabbit mAb (solid lines) or a concentration-matched Rabbit (DA1E) mAb IgG XP^® Isotype Control #3900 (dashed lines). Anti-rabbit IgG (H+L), F(ab')₂ Fragment (Alexa Fluor^® 488 Conjugate) #4412 was used as a secondary antibody.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 24 — Immunohistochemical analysis of paraffin-embedded human lung adenocarcinoma using Periostin (E5F2S) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 25 — Immunohistochemical analysis of paraffin-embedded human neuroendocrine carcinoma of the lung using Fibronectin/FN1 (E5H6X) Rabbit mAb performed on the Leica^® BOND^™ Rx.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 26 — Confocal immunofluorescent analysis of RH-30 cells (left, high-expressing) or HCT 116 cells (right, low-expressing) using Tenascin C (E5J3B) Rabbit mAb (green). Actin filaments were labeled with DyLight^™ 554 Phalloidin #13054 (red). Sections were mounted in ProLong^® Gold Antifade Reagent with DAPI #8961 (blue).

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 27 — Immunohistochemical analysis of paraffin-embedded human lung sarcoma using COL3A1 (E8D7R) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 28 — Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using COL1A1 (E8F4L) XP^® Rabbit mAb performed on the Leica^® BOND^™ Rx.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 29 — Immunohistochemical analysis of paraffin-embedded human lung carcinoma using SPARC (D10F10) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 30 — Immunohistochemical analysis of paraffin-embedded human renal cell carcinoma using Periostin (E5F2S) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 31 — Immunohistochemical analysis of paraffin-embedded Hep G2 cell pellet (left, positive) or PANC-1 cell pellet (right, negative) using Fibronectin/FN1 (E5H6X) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 32 — Immunohistochemical analysis of paraffin-embedded human large cell neuroendocrine lung carcinoma using COL3A1 (E8D7R) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 33 — Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using COL1A1 (E8F4L) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 34 — Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using Periostin (E5F2S) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 35 — Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using Fibronectin/FN1 (E5H6X) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 36 — Immunohistochemical analysis of paraffin-embedded human urothelial carcinoma using COL3A1 (E8D7R) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 37 — Immunohistochemical analysis of paraffin-embedded normal human kidney using COL1A1 (E8F4L) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 38 — Immunohistochemical analysis of paraffin-embedded 293T cell pellet, untransfected (left) or periostin-transfected (right), using Periostin (E5F2S) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 39 — Immunohistochemical analysis of paraffin-embedded human ductal breast carcinoma using Fibronectin/FN1 (E5H6X) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 40 — Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using COL3A1 (E8D7R) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 41 — Immunohistochemical analysis of paraffin-embedded human esophageal adenocarcinoma using COL1A1 (E8F4L) XP^® Rabbit mAb (left) compared to concentration-matched Rabbit (DA1E) mAb IgG XP^® Isotype Control #3900 (right).

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 42 — Immunohistochemical analysis of paraffin-embedded human breast carcinoma using Periostin (E5F2S) Rabbit mAb (left) compared to concentration-matched Rabbit (DA1E) mAb IgG XP^® Isotype Control #3900 (right).

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 43 — Immunohistochemical analysis of paraffin-embedded human adenoid cystic carcinoma of the trachea using Fibronectin/FN1 (E5H6X) Rabbit mAb (left) or Fibronectin Rabbit mAb (right). These two antibodies detect independent, unique epitopes on human Fibronectin/FN1 protein. The similar staining patterns obtained with both antibodies help to confirm the specificity of the staining.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 44 — Immunohistochemical analysis of paraffin-embedded normal human kidney using COL3A1 (E8D7R) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 45 — Immunohistochemical analysis of paraffin-embedded mouse liver using COL1A1 (E8F4L) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 46 — Immunohistochemical analysis of paraffin-embedded Hs 578T cell pellet (left, positive) or AN3-CA cell pellet (right, negative) using Periostin (E5F2S) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 47 — Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using Fibronectin/FN1 (E5H6X) Rabbit mAb (left) compared to concentration-matched Rabbit (DA1E) mAb IgG XP^® Isotype Control #3900 (right).

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 48 — Immunohistochemical analysis of paraffin-embedded human endometrioid adenocarcinoma using COL3A1 (E8D7R) XP^® Rabbit mAb (left) compared to concentration-matched Rabbit (DA1E) mAb IgG XP^® Isotype Control #3900 (right).

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 49 — Immunohistochemical analysis of paraffin-embedded mouse lung using COL1A1 (E8F4L) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 50 — Immunohistochemical analysis of paraffin-embedded human lung adenocarcinoma using Fibronectin/FN1 (E5H6X) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 51 — Immunohistochemical analysis of paraffin-embedded RD cell pellet (left, positive) or ACHN cell pellet (right, negative) using COL3A1 (E8D7R) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 52 — Immunohistochemical analysis of paraffin-embedded A20 syngeneic tumor using COL1A1 (E8F4L) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 53 — Immunohistochemical analysis of paraffin-embedded human B-cell non-Hodgkin lymphoma using Fibronectin/FN1 (E5H6X) Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 54 — Immunohistochemical analysis of paraffin-embedded GL261 syngeneic tumor using COL1A1 (E8F4L) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 55 — Confocal immunofluorescent analysis of U-118 MG cells (left, positive) and PANC-1 cells (right, negative) using Fibronectin/FN1 (E5H6X) Rabbit mAb (green). Actin filaments were labeled with DyLight^™ 650 Phalloidin #12956 (red). Samples were mounted in ProLong^® Gold Antifade Reagent with DAPI #8961 (blue).

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 56 — Immunohistochemical analysis of paraffin-embedded U-118 MG cell pellet (left, positive) or HT-29 cell pellet (right, negative) using COL1A1 (E8F4L) XP^® Rabbit mAb.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 57 — Immunohistochemical analysis of paraffin-embedded human colon carcinoma (left), renal cell carcinoma (middle) or prostate carcinoma (right) using COL1A1 (E8F4L) XP^® Rabbit mAb (top) or COL1A1 (E3E1X) Mouse mAb #66948 (bottom). These two antibodies detect independent, unique epitopes on human COL1A1. The similar staining patterns obtained with both antibodies help to confirm the specificity of the staining.

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 58 — Confocal immunofluorescent analysis of mouse spleen using COL1A1 (E8F4L) XP^® Rabbit mAb (green). After blocking free secondary antibody binding sites with Rabbit (DA1E) mAb IgG XP^® Isotype Control #3900, the tissue was then labeled using Non-phospho (Active) β-Catenin (Ser45) (D2U8Y) XP^® Rabbit mAb (Alexa Fluor^® 488 Conjugate) #70034 (cyan pseudocolor) and α-Smooth Muscle Actin (D4K9N) XP^® Rabbit mAb (Alexa Fluor^® 594 Conjugate) #36110 (red). Samples were mounted in ProLong^® Gold Antifade Reagent with DAPI #8961 (blue).

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 59 — Confocal immunofluorescent analysis of mouse colon using COL1A1 (E8F4L) XP^® Rabbit mAb (green). After blocking free secondary antibody binding sites with Rabbit (DA1E) mAb IgG XP^® Isotype Control #3900, the tissue was then labeled using Non-phospho (Active) β-Catenin (Ser45) (D2U8Y) XP^® Rabbit mAb (Alexa Fluor^® 488 Conjugate) #70034 (cyan pseudocolor) and α-Smooth Muscle Actin (D4K9N) XP^® Rabbit mAb (Alexa Fluor^® 594 Conjugate) #36110 (red). Samples were mounted in ProLong^® Gold Antifade Reagent with DAPI #8961 (blue).

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 60 — Confocal immunofluorescent analysis of mouse liver using COL1A1 (E8F4L) XP^® Rabbit mAb (green). After blocking free secondary antibody binding sites with Rabbit (DA1E) mAb IgG XP^® Isotype Control #3900, the tissue was then labeled using Non-phospho (Active) β-Catenin (Ser45) (D2U8Y) XP^® Rabbit mAb (Alexa Fluor^® 488 Conjugate) #70034 (cyan pseudocolor) and α-Smooth Muscle Actin (D4K9N) XP^® Rabbit mAb (Alexa Fluor^® 594 Conjugate) #36110 (red). Samples were mounted in ProLong^® Gold Antifade Reagent with DAPI #8961 (blue).

Extracellular Matrix Dynamics Antibody Sampler Kit: Image 61 — Confocal immunofluorescent analysis of U-118 MG cells (left, positive) and HT-29 cells (right, negative) using COL1A1 (E8F4L) XP^® Rabbit mAb (green). Actin filaments were labeled with DyLight^™ 554 Phalloidin #13054 (red). Samples were mounted in ProLong^® Gold Antifade Reagent with DAPI #8961 (blue).

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To Purchase # 63387

Cat. #	Size	Qty.	Price	Inventory
63387T	1 Kit (9 x 20 microliters)

Product Includes
Related Products

Product Includes	Quantity	Applications	Reactivity	MW(kDa)	Isotype
COL1A1 (E8F4L) XP^® Rabbit mAb 72026	20 µl	WB IHC IF	H M	220	Rabbit IgG
Tenascin C (E5J3B) Rabbit mAb 33352	20 µl	WB IP IF	H	200, 240	Rabbit IgG
Thrombospondin-1 (D7E5F) Rabbit mAb 37879	20 µl	WB IP	H M R	170	Rabbit IgG
Fibronectin/FN1 (E5H6X) Rabbit mAb 26836	20 µl	WB IP IHC IF	H	300	Rabbit IgG
COL4A1 Antibody 50273	20 µl	WB	H	200	Rabbit
SPARC (D10F10) Rabbit mAb 8725	20 µl	WB IHC	H M	42	Rabbit IgG
Periostin (E5F2S) Rabbit mAb 20302	20 µl	WB IP IHC	H	90	Rabbit IgG
Anti-rabbit IgG, HRP-linked Antibody 7074	100 µl	WB			Goat
COL3A1 (E8D7R) XP^® Rabbit mAb 63034	20 µl	WB IHC	H	200	Rabbit IgG
CYR61 (D4H5D) XP^® Rabbit mAb 14479	20 µl	WB IF F	H	41	Rabbit IgG

Kit Usage Information

Protocols

7074: Western Blotting
8725: Western Blotting, Immunohistochemistry (Paraffin)
14479: Western Blotting, Immunofluorescence*, Flow
20302: Western Blotting, Immunoprecipitation (Magnetic), Immunohistochemistry (Paraffin)
26836: Western Blotting, Immunoprecipitation (Agarose), Immunohistochemistry (Leica® Bond™), Immunohistochemistry (Paraffin), Immunofluorescence
33352: Western Blotting, Immunoprecipitation (Agarose), Immunofluorescence
37879: Western Blotting, Immunoprecipitation (Magnetic)
50273: Western Blotting
63034: Western Blotting, Immunohistochemistry (Paraffin)
72026: Western Blotting, Immunohistochemistry (Leica® Bond™), Immunohistochemistry (Paraffin), Immunofluorescence, Immunofluorescence

Product Description

The Extracellular Matrix Dynamics Antibody Sampler Kit provides an economical means of detecting selected proteins associated with dynamic remodeling of the extracellular matrix. The kit includes enough antibodies to perform two western blot experiments with each primary antibody.

Specificity / Sensitivity

Each antibody in the Extracellular Matrix Dynamics Antibody Sampler Kit detects endogenous levels of its target protein. Periostin (E5F2S) Rabbit mAb recognizes endogenous levels of total human periostin protein. The antibody also weakly detects a 40 kDa protein of unknown identity.

Source / Purification

Monoclonal antibodies are produced by immunizing animals with recombinant proteins specific to the carboxy terminus of human Tenascin C protein and human Fibronectin/FN1 protein; with synthetic peptides corresponding to residues surrounding Phe1197 of human COL1A1 protein, Ser395 of human periostin protein, and Pro171 of human CYR61 protein, the amino terminus of human thrombospondin-1 protein and human SPARC protein, and the carboxy terminus of human COL3A1 protein. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp536 of human COL4A1 protein. Antibodies are purified by peptide affinity chromatography.

Background

The extracellular matrix (ECM) is a three-dimensional macromolecular network composed of collagens, proteoglycans, glycosaminoglycans, elastin, fibronectin, laminins, along with many other proteins and glycoproteins. This network of macromolecules provides a dynamic microenvironment that supports cell and tissue function, and undergoes continuous remodeling during both normal development and disease (1). Remodeling of the ECM can alter the relative balance of macromolecules within distinct ECM subcompartments, with important functional consequences; for example, changes to the relative amounts of COL1A1 and COL3A1 in the interstitial ECM, or COL4A1 and laminins in the basement membrane, can influence cell-matrix interactions, and/or disrupt cellular signaling events (2). Fibronectin functions as a physical and functional bridge between many different ECM components, including collagens, growth factors, and cell surface integrins, and thus plays a critical role in facilitating ECM remodeling. Matricellular proteins (MCPs) are another important group of ECM proteins. MCPs can be categorized into 6 distinct subgroups: centralized coordination network (CCN), thrombospondin (THBS), secreted protein acidic and rich in cysteine (SPARC), tenascin (TN), small integrin-binding ligand N-linked glycoprotein (SIBLING), and γ-carboxyglutamate (Gla)-containing proteins. CCN1 (CYR61), SPARC, tenascin C, periostin, and thrombospondin-1 are among the most well-studied of this group. All are non-structural ECM proteins that interact with structural ECM proteins, in part to regulate the rigidity of the ECM. They also play important roles in matrix-cell communication by engaging with cell surface receptors and integrins to elicit intracellular responses. The dysregulation of MCP expression has been associated with the development of numerous disease states, including cancer and fibrosis (4,5).

Pathways & Proteins

Explore pathways + proteins related to this product.

Database Links

UniProt ID: P02462 , P02751 , O00622 , P02452 , Q15063 , P09486 , P07996 , P24821 , P02461

Entrez-Gene Id: 1282 , 2335 , 3491 , 1277 , 10631 , 6678 , 7057 , 3371 , 1281

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Extracellular Matrix Dynamics Antibody Sampler Kit #63387